Masteries are the usual 9/0/21 build with ignite + flash or ghost.
The skill order is:
Ability | Level | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Crimson Pact | ||||||||||||||||||
![]() | Transfusion | ![]() | ![]() | ![]() | ![]() | ![]() | |||||||||||||
![]() | Sanguine Pool | ![]() | ![]() | ![]() | ![]() | ![]() | |||||||||||||
![]() | Tides of Blood | ![]() | ![]() | ![]() | ![]() | ![]() | |||||||||||||
![]() | Hemoplague | ![]() | ![]() | ![]() |
Items are:

Amplifying Tome
435

Health Potion
35

Sorcerer's Shoes
1100

Mejai's Soulstealer
800

Rabadon's Deathcap
3600

Zhonya's Hourglass
3300

Rylai's Crystal Scepter
3105

Lich Bane
3470
Runes are:

Greater Mark of Insight
9

Greater Seal of Fortitude
9

Greater Glyph of Force
9

Greater Quint of Fortitude
3
Tips and tricks:
1. You can use Sanguine Pool to Permanently drop aggro from turrets EVEN AFTER damaging enemy champions, AS long as their is another target for the turret to fire upon. Ex: A friendly minion, pet, or even another champion.
2. Your Ultimate(Hemoplague) has an excellent reach, See someone recalling too close to their turret but are low health? You can cast your ult on them from outside the turret's range as long as you hit them with just the outside edge of the spell.
3. Level 13+ Don't be afraid to turret dive, Run in and smack the enemy with a Transfusion or your Ultimate and then useSanguine Pool for an easy escape. By level 13+ your Sanguine Pool cooldown should be low enough so that it will be up the next time you need it.
4. Never initiate with your Sanguine Pool, Save it for extra damage after your ultimate(Level 13+ So the cooldown is shorter) or during iffy battles to help with your retreat.
5. Gank! Vladamir is an excellent ganker. If you are playing center, watch the top and bottom lanes constantly and work with your teammates to set up traps for the enemy champions who push a little too far into your territory. Try to get behind them and use your Sanguine Pool (If it is safe to do so) to slow them down for your friendly champs.
6. Average speed melee chasing you? Do you have Rylai's Crystal Scepter? If so, Cast Transfusion on every cooldown while running. The slow from Rylai's will help you to keep your distance while allowing you to get your health up and maybe even get the advantage on your opponent.
2. Your Ultimate(Hemoplague) has an excellent reach, See someone recalling too close to their turret but are low health? You can cast your ult on them from outside the turret's range as long as you hit them with just the outside edge of the spell.
3. Level 13+ Don't be afraid to turret dive, Run in and smack the enemy with a Transfusion or your Ultimate and then useSanguine Pool for an easy escape. By level 13+ your Sanguine Pool cooldown should be low enough so that it will be up the next time you need it.
4. Never initiate with your Sanguine Pool, Save it for extra damage after your ultimate(Level 13+ So the cooldown is shorter) or during iffy battles to help with your retreat.
5. Gank! Vladamir is an excellent ganker. If you are playing center, watch the top and bottom lanes constantly and work with your teammates to set up traps for the enemy champions who push a little too far into your territory. Try to get behind them and use your Sanguine Pool (If it is safe to do so) to slow them down for your friendly champs.
6. Average speed melee chasing you? Do you have Rylai's Crystal Scepter? If so, Cast Transfusion on every cooldown while running. The slow from Rylai's will help you to keep your distance while allowing you to get your health up and maybe even get the advantage on your opponent.
Hope you enjoy!